β-lactam-cannabinoid conjugate molecules
AssigneeDiverse Biotech, Inc.
InventorPaul Hershberger
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Abstract
This disclosure provides multifunctional conjugate molecules in which at least one β-lactam antibiotic is covalently attached to a cannabinoid by means of a linker. The disclosed conjugate molecules are designed to deliver therapeutic benefits as intact molecules, with release of the cannabinoid upon binding of the β-lactam antibiotic to its target conveying further therapeutic benefits, and can be used to treat bacterial infections and other disorders.
Claims18
A conjugate molecule, or a pharmaceutically acceptable salt thereof, comprising a first β-lactam antibiotic component, a first linker, and a cannabinoid component, wherein the first linker is covalently attached to a first hydroxy group of the cannabinoid component, wherein:
- (a) the first β-lactam antibiotic component is selected from the group consisting of a first cephem component, a first carbacephem component, a first penem component, and a first carbapenem component covalently attached at its 3 position to the first linker;
- or
- (b) the first β-lactam antibiotic component is a first monobactam component covalently attached at its 2 position to the first linker.
Dependencies are inferred from the claim text.