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US 12,257,302 B2Granted
Universal vaccine platform
AssigneeArizona Board of Regents on behalf of Arizona State University
InventorsHugh Mason, Andrew Diamos, Mary Pardhe, Brandon Favre
Life of this patent
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Abstract
The disclosure relates to vaccination compositions, for example, against human papillomavirus, Zika virus, and flu virus. The disclosure also relates to vectors for producing the virus-like particles and immune complex platforms of the vaccination compositions.
Claims17
A recombinant immune complex comprising:
- an immunoglobulin heavy chain;
- an immunoglobulin light chain;
- an epitope tag, wherein the immunoglobulin heavy chain binds the epitope tag;
- and a fragment of a virus protein, wherein the fragment of the virus protein is linked to the N-terminus of the immunoglobulin heavy chain, the epitope tag is linked to the C-terminus of the immunoglobulin heavy chain, and the epitope tag is from a different protein than the virus protein.
1 more element
A method of generating an immune response against a virus in a mammalian subject, the method comprising administering to the mammalian subject a recombinant immune complex (RIC), the RIC comprising:
- an immunoglobulin heavy chain;
- an epitope tag, wherein the immunoglobulin heavy chain binds the epitope tag;
- and
- a fragment of the virus protein,
- wherein the fragment of the virus protein is linked to the C-terminus of the immunoglobulin heavy chain, the epitope tag is linked to the C-terminus of the fragment of the virus protein, and the epitope tag is from a different protein than the virus protein.
2 more elements
Dependencies are inferred from the claim text.