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US 12,257,249 B2Granted
Methods for treating depressive symptoms
AssigneeAlkermes Pharma Ireland Limited
InventorsLaura Cook Blumberg, Daniel R. Deaver, David J. Eyerman, Thomas Andrew Wynn
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Abstract
The present application relates methods for treating a depressive symptom comprising administering an effective amount of a μ opioid receptor agonist or a pharmaceutically acceptable salt thereof to a subject in need thereof. Non-limiting examples of such agonist include the compounds of Formulas I, II, III, and IV, as well as the compounds of Table A.
Claims15
A method of treating a depressive symptom in a subject comprising administering to the subject a compound selected from:
- or a pharmaceutically acceptable salt thereof;
- wherein the depressive symptom is depressed mood, loss of pleasure, loss of appetite, sleep disturbance, psychomotor changes, fatigue, post-partum depression, associated with a mental condition, acute stress disorder, adjustment disorders with depressed mood, Asperger syndrome, attention deficit, bereavement, bipolar I disorder, bipolar II disorder, borderline and personality disorder, cyclothymia and dysthymia, major depressive disorder (MDD), treatment-resistant disorder (TRD), Dysthymic disorder, hyperactivity disorder, impulse control disorder, mixed mania, obsessive-compulsive personality disorder (OCD), paranoid, post-traumatic stress disorder, seasonal affective disorder, self-injury separation, sleep disorder, substance-induced mood disorder, Tourette syndrome and tic disorder, Trichotillomania, or an anxiety disorder.
Dependencies are inferred from the claim text.