Preparation method for three-layer artificial blood vessel and application thereof

A preparation method for three-layer artificial blood vessel, including the following steps:

• S1:
• dissolving a macromolecular compound into a solvent to obtain an electrospinning solution with a concentration of 5-30% w/v and an electric-spray solution with a concentration of 10-60% w/v;
• S2:
• placing the electrospinning solution obtained in S1 over a mandrel device and performing electrospinning to obtain a porous electrospun inner layer, drying the inner layer to remove the residual solvent;
• S3:
• with the inner layer obtained in S2 as a receiving surface, performing first electric spray, second electric spray, . . . nth electric spray with the electric-spray solution to obtain a dense middle layer, wherein a process of the first electric spray includes spraying, stopping, spraying, stopping, . . . repeated cycles, a time of the stopping in the process of the first electric spray is 5-20 min;
• and a time of each of the first electric spray, the second electric spray and the nth electric spray is 5-50 min;
• and
• S4:
• with the dense middle layer obtained in S3 as a receiving surface, performing electrospinning, and then drying to obtain the three-layer artificial blood vessel.