Methods and compositions for treating asthma and allergic diseases

A method of treating allergic disease in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an inhibitor of PCSK9, wherein the allergic disease is asthma or food allergy, and wherein the method comprises predicting whether the subject is at risk of having the allergic disease by

• i) determining the PCSK9 level in a biological sample obtained from the subject,
• ii) comparing the level determined at step i) with a predetermined reference value
• iii) concluding that the subject has or is susceptible to have severe allergic disease when the level of PCSK9 is higher than the predetermined reference value, and
• iv) administering the therapeutically effective amount of the inhibitor of PCSK9.

A method of treating or inhibiting severe asthma or food allergy in a subject in need thereof, comprising

• i) measuring a PCSK9 level in a biological sample obtained from the subject,
• ii) comparing the level determined at step i) with a predetermined reference value
• iii) determining that the subject has or is susceptible to have severe asthma or food allergy when the level of PCSK9 is higher than the predetermined reference value, and
• iv) administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising an inhibitor of PCSK9 selected from the group consisting of alirocumab, evolocumab and bococizumab.