Preparation methods of quinolone compounds and intermediates thereof

A process for the preparation of a compound of Formula I, comprising the steps of:

• i) reacting a compound of Formula A with R5NH2 and R6Cl in the presence of a base to form a compound of Formula B, and
• ii) reacting the compound of Formula B in the presence of a base to form the compound of Formula I,
• wherein the reaction of step ii) is carried out at a temperature higher than the reaction temperature of step i);
• wherein:
• X is selected from the group consisting of CR2 and N;
• Z is selected from the group consisting of CR4 and N;
• R1 is independently selected from the group consisting of hydrogen, alkyl, alkoxy, halo, NO2, CN, optionally substituted amino, haloalkyl, aryl, and heteroaryl;
• R2 and R3 are each independently selected from the group consisting of hydrogen, alkyl, alkoxy, halo, amino, NO2, CN, haloalkyl, aryl, and heteroaryl;
• or R2 and R3 are linked together to form a ring;
• R4 is independently selected from the group consisting of hydrogen, alkyl, alkoxy, halo, amino, NO2, CN, haloalkyl, aryl, and heteroaryl;
• R5 is independently selected from the group consisting of alkyl optionally substituted with OH or SH;
• cycloalkyl optionally substituted with halo;
• aryl;
• and heteroaryl;
• and
• R6 is independently selected from sulfonyl.