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US 12,252,464 B2Granted
Cationic sulfonamide amino lipids and amphiphilic zwitterionic amino lipids
AssigneeBoard of Regents, The University of Texas System
InventorsDaniel J. Siegwart, Jason B. Miller
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Abstract
The present disclosure provides one or more amino lipids such as an amino lipids containing a sulfonic acid or sulfonic acid derivative of the formulas: wherein the variables are as defined herein. These amino lipids may be used in compositions with one or more helper lipids and a nucleic acid therapeutic agent. These compositions may be used to treat a disease or disorder such as cancer, cystic fibrosis, or other genetic diseases.
Claims19
A pharmaceutical composition comprising:
- (a) a polynucleotide;
- (b) a lipid composition comprising a zwitterionic aminolipid comprising an alkylated phosphate anion having the structure:
- wherein, * indicates a point of attachment of a quaternary ammonium cation to said alkylated phosphate anion, wherein said quaternary ammonium cation comprises the structure:
- wherein, ** indicates a point of attachment of said quaternary ammonium cation to said alkylated phosphate anion;
- R1 is a first lipid group;
- and
- each R2 is independently H or a second lipid group.
4 more elements
Dependencies are inferred from the claim text.