Devices and methods for the integrated filtration, drying, and mechanical processing of active pharmaceutical ingredients

A filtration device, comprising:

• a housing;
• a porous filtration medium (170) spanning a cross-section of the housing dividing the housing into a prefilt volume and a filtrate volume;
• and
• an impeller (120) disposed within the prefilt volume of the housing, the impeller including:
• a rotatable shaft (130);
• and
• a rotatable edge (143) attached to an end of the rotatable shaft (130) adjacent to a surface of the porous filtration medium (170) and spaced from the porous filtration medium (170) a distance of one millimeter or less, the rotatable edge (143) having at least twenty protrusions (141) extending toward the porous filtration medium (170), the protrusions (141) having a protruding dimension (145) of greater than or equal to one millimeter and less than or equal to two centimeters, the at least twenty protrusions (141) have an average spacing (144) of greater than or equal to one millimeter and less than or equal to one centimeter;
• wherein rotation of the rotatable shaft (130) causes the rotatable edge (143) to sweep an area of the porous filtration medium (170) during rotation and break up solid material contained on the porous filtration medium (170) and produce a flowable powder having a flow function coefficient of less than or equal to 10.