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US 12,251,444 B2Granted
Compositions and methods for delivering an agent to a wound
AssigneeThe University of Memphis Research Foundation
InventorsWarren O. Haggard, Scott P. Noel, Joel D. Bumgardner
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Abstract
The invention provides compositions featuring chitosan and methods for using such compositions for the local delivery of biologically active agents to an open fracture, complex wound or other site of infection. Advantageously, the degradation and drug elution profiles of the chitosan compositions can be tailored to the needs of particular patients at the point of care (e.g., in a surgical suite, clinic, physician's office, or other clinical setting).
Claims4
A medical device for implantation comprising an acid-treated chitosan composition, prepared by a method comprising:
- (a) dissolving chitosan in one or more acids in an aqueous solvent;
- (b) forming the chitosan of step (a) into a film by pouring the chitosan into a thin layer and heating the chitosan to form a dehydrated chitosan film;
- (c) lyophilizing the chitosan film under conditions that reduce the water content by about 10%-100%;
- (d) neutralizing the chitosan film by contacting the film with water, a neutral, or a basic solution, wherein the water, neutral, or basic solution is selected to modulate a physical-mechanical property of the fiber;
- (e) washing the chitosan film with water until neutral;
- and
- (f) lyophilizing the film of step (e) to reduce the water content by about 80%-100%, thereby producing a biodegradable chitosan film.
4 more elements
Dependencies are inferred from the claim text.