Biomarkers and immunogenic compositions for filarial parasites
AssigneesNew York Blood Center, Inc., The United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsSara Lustigman, Thomas B. Nutman, Sasisekhar Bennuru
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Abstract
Disclosed herein are immunogenic compositions for preventing or treating infection with filarial parasites and biomarkers for diagnosing infection with filarial parasites.
Claims10
An immunogenic composition for administration to a canine subject, the composition comprising isolated Dirofilaria immitis proteins consisting of:
- a first protein having at least 95% sequence identity to SEQ ID NO:48 and a second protein having at least 95% sequence identity to the full length mature amino acid sequence of SEQ ID NO:
- 49;
- and
- an adjuvant.
An immunogenic composition for administration to a canine subject, the composition comprising:
- (a) isolated Dirofilaria immitis proteins consisting of:
- (i) a first protein having at least 95% sequence identity to SEQ ID NO:48;
- (ii) a second protein having at least 95% sequence identity to the full length mature amino acid sequence of the D. immitis protein of one of SEQ ID NOs:
- 33-47 or 49;
- and
- (iii) a third protein having at least 95% sequence identity to the full length mature amino acid sequence of the D. immitis protein of one of SEQ ID NOs:
- 33-47 or 49;
- and
- (b) an adjuvant;
- wherein the second and third proteins are different proteins, and wherein the immunogenic composition induces an immune response against the D. immitis proteins in the canine subject.
An immunogenic composition for administration to a canine subject, the composition consisting essentially of:
- (a) isolated Dirofilaria immitis proteins consisting of:
- (i) a first protein having at least 95% sequence identity to SEQ ID NO:48 and
- (ii) a second protein having at least 95% sequence identity to the full length mature amino acid sequence of SEQ ID NO:49;
- and
- (b) an adjuvant.
Dependencies are inferred from the claim text.