Sustained-release microparticles containing deslorelin, and preparation method therefor

A method for preparing sustained-release microparticles containing deslorelin, the method comprising steps of:

• 1) preparing a first mixture by mixing an active pharmaceutical ingredient (API) mixture in which deslorelin is dissolved in a first solvent and a biodegradable polymer mixture in which a biodegradable polymer is dissolved in a second solvent;
• 2) dissolving a surfactant in water to prepare a second mixture;
• 3) injecting the first mixture of the step 1) into a channel in a linear direction and allowing the first mixture to flow therein;
• 4) injecting the second mixture of the step 2) into a channel formed on either side or one side so as to form a cross-point with the channel in which the first mixture of the step 3) flows in the linear direction and allowing the second mixture to flow therein, and then crossing the flow in the linear direction with the flow in a lateral direction to prepare microparticles in which deslorelin is evenly distributed;
• 5) collecting the microparticles generated at the cross-point of the step 4);
• 6) removing an organic solvent present on the surface of the microparticles collected in the step 5);
• and
• 7) washing and drying the microparticles of the step 6),
• wherein the prepared microparticles are an O1 (Oil)/O2 (Oil)/W (Water) emulsion or a W1 (Water)/O (Oil)/W2 (Water) emulsion, and have an average diameter of 25 to 140 μm.