Synthesis and antimicrobial uses of dinuclear silver(I) pyrazolates

A method of synthesizing a dinuclear silver (I) pyrazolido complex, the method comprising the steps of:

• providing silver oxide (Ag2O) or AgL precursor;
• wherein AgL is selected from the group consisting of silver acetate, silver benzoate, silver trifluorosulfonate, silver nitrate, and silver chloride;
• providing a pyrazole derivative, wherein the pyrazole derivative comprises independent substituents at R3, R4, and R5 selected from the group consisting of hydrogen, halogen, hydroxyl, nitro, alkyl, alkenyl, aryl, formyl, acetyl, halogen substituted alkyl, halogen substituted aryl, halogen substituted sulfuryl, imine-linked PTA, amine-linked PTA, imine-linked adamantane, amine-linked adamantine, imine-linked triphenylphosphine, and amine-linked triphenylphosphine;
• reacting the pyrazole derivative with the silver oxide or silver precursor in equimolar ratios at ambient conditions to generate a polymer having a general formula of [Ag(pz*)]n, wherein pz* is a substituted pyrazolido anion;
• optionally, purifying said polymer;
• and
• reacting the polymer with a phosphine selected from the group consisting of phosphaadamantane (PA), phenanthrene diphenylphosphine (PDPP), 8-((4-phosphino)phenyl)-4,4-dimethyl-1,3,5,7-tetramethyl-2,6-diethyl-4-bora-3a,4a-diaza-s-indacene (PMBODIPY), 8-((4-phosphino) phenyl)-4,4-diethyl-1,3,5,7-tetramethyl-2,6-diethyl-4-bora-3a,4a-diaza-s-indacene (PEBODIPY), and 8-((4-phosphino) phenyl)-4,4-diphenyl-1,3,5,7-tetramethyl-2,6-diethyl-4-bora-3a,4a-diaza-s-indacene (PPBODIPY).