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US 12,247,920 B2Granted
Methods and systems for transmission and detection of free radicals
AssigneeWisconsin Alumni Research Foundation
InventorsJ. Leon Shohet, Michael R. Sussman, Faraz A. Choudhury, Benjamin B. Minkoff, Grzegorz Sabat, Joshua M. Blatz
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Abstract
The present disclosure provides systems and methods for characterizing the interaction of free radicals with various materials and the use of known interactions to isolate free radical generation from free radical interaction with a target molecule.
Claims18
A system comprising:
- a free radical generation chamber;
- a free radical source positioned within the free radical generation chamber, the free radical source configured to generate one or more free radicals;
- an interaction chamber;
- and
- a free radical transmitting barrier positioned between the free radical generation chamber and the interaction chamber, the free radical transmitting barrier comprising a barrier material having a known response to interaction with the one or more free radicals.
2 more elements
A method comprising:
- a) generating a plurality of free radicals from a free radical source, the free radical source positioned on a first side of a material of interest that is opposite a second side of the material of interest, wherein the plurality of free radicals is moving in a direction toward the material of interest;
- b) measuring a measurable change in at least one property of a free radical detection species positioned on the second side of the material of interest, the measuring occurring after a length of time where at least a portion of the plurality of free radicals have passed through the material of interest and interacted with the free radical detection species, the free radical detection species undergoing the measurable change in at least one property after interaction with one or more of the plurality of free radicals.
A method of modifying a target molecule located in a sample, the sample located in an interaction chamber positioned on a second side of a free radical transmitting barrier, the method comprising:
- a) generating a plurality of free radicals from a free radical source, the free radical source positioned in a free radical generation chamber positioned on a first side of the free radical transmitting barrier that is opposite the second side, wherein the plurality of free radicals is moving in a direction toward the free radical transmitting barrier and the interaction chamber;
- and
- b) waiting a length of time sufficient for one or more of the plurality of free radicals to pass through the free radical transmission barrier and interact with the target molecule, thereby modifying the target molecule.
Dependencies are inferred from the claim text.