Photo-coupled synergistically crosslinked hydrogel material and its composition, preparation method, use, product, and preparation kit

A photosensitive polymer derivative having an o-nitrobenzyl phototrigger, wherein

• the o-nitrobenzyl phototrigger is an o-nitrobenzyl sulfide phototrigger, an o-nitrobenzyl amine phototrigger, a cyclic o-nitrobenzyl phototrigger, a cyclic o-nitrobenzyl sulfide phototrigger, or a cyclic o-nitrobenzylamine phototrigger,
• the polymer derivative having the o-nitrobenzyl sulfide phototrigger has the structure of Formula A-I,
• the polymer derivative having the o-nitrobenzyl amine phototrigger has the structure of Formula A-II,
• the polymer derivative having the cyclic o-nitrobenzyl sulfide phototrigger and the polymer derivative having the cyclic o-nitrobenzylamine phototrigger have the structure of Formula A-III, respectively,
• in the Formula A-I, A-II and A-III, R′ is selected from the group consisting of a hydrogen atom, a halogen atom, a hydroxyl group, a sulfhydryl group, an amine group, a nitro group, a cyano group, an aldehyde group, a ketone group, an ester group, an amide group, a phosphonic acid group, a phosphonate group, a sulfonic group, a sulfonate group, a sulfone group, a sulfoxide group, an aryl group, an heteroaryl group, an alkyl group, an alkylene group, a modified alkyl group, and a modified alkylene group,
• in the Formula A-I, A-II and A-III, R1 includes one selected from the group consisting of a hydrogen atom, an ether group, an ester group, a carbonate group, a urethane group, a mercapto formate group, and a phosphate group,
• in the Formula A-I, A-II and A-III, R2, R3, R4, and R5 each independently includes one selected from the group consisting of a hydrogen atom, a halogen atom, a hydroxyl group, a sulfhydryl group, an amine group, a nitro group, a cyano group, an aldehyde group, a ketone group, an ester group, an amide group, a phosphonic acid group, a phosphonate group, a sulfonic group, a sulfonate group, a sulfone group, a sulfoxide group, an aryl group, an heteroaryl group, an alkyl group, an alkylene group, a modified alkyl group, and a modified alkylene group,
• in the Formula A-I, A-II, and A-III, n≥2,
• in the Formula A-I, A-II, and A-III, P1 includes one or more of hydrophilic or water-soluble natural polymers or synthetic polymers,
• in the Formula A-III, X is S or NH, R1 is directly bonded to X, and R1 is directly bonded to one of R2, R3, R4, and R5 to form a cyclic structure,
• in the Formula A-I, A-II, and A-III, two or more of R2, R3, R4, and R5 are connected to form a saturated or unsaturated alicyclic ring, alicyclic heterocycle, aromatic ring, or aromatic heterocycle, together with carbon atom(s).

A kit for preparing a photo-coupled synergistically crosslinked hydrogel material, comprising component A and instructions for preparation and application of the photo-coupled synergistically crosslinked hydrogel,

• the component A includes a polymer derivative having an o-nitrobenzyl phototrigger selected from the group consisting of a polymer derivative having the structure of Formula A-I, a polymer derivative having the structure of Formula A-II, and a polymer derivative having the structure of Formula A-III,
• where, in the Formula A-I, A-II, and A-III, R′ is selected from the group consisting of a hydrogen atom, a halogen atom, a hydroxyl group, a sulfhydryl group, an amine group, a nitro group, a cyano group, an aldehyde group, a ketone group, an ester group, an amide group, a phosphonic acid group, a phosphonate group, a sulfonic group, a sulfonate group, a sulfone group, a sulfoxide group, an aryl group, a heteroaryl group, an alkyl group, an alkylene group, a modified alkyl group, and a modified alkylene group,
• in the Formula A-I, A-II and A-III, R1 is selected from the group consisting of a hydrogen atom, an ether group, an ester group, a carbonate group, a urethane group, a mercapto formate group, and a phosphate group,
• in the Formula A-I, A-II and A-III, R2, R3, R4, and R5 each independently includes one selected from the group consisting of a hydrogen atom, a halogen atom, a hydroxyl group, a sulfhydryl group, an amine group, a nitro group, a cyano group, an aldehyde group, a ketone group, an ester group, an amide group, a phosphonic acid group, a phosphonate group, a sulfonic group, a sulfonate group, a sulfone group, a sulfoxide group, an aryl group, a heteroaryl group, an alkyl group, an alkylene group, a modified alkyl group, and a modified alkylene group,
• in the Formula A-I, A-II, and A-III, n≥2,
• in the Formula A-I, A-II and A-III, P1 includes one or more of hydrophilic or water-soluble natural polymers or synthetic polymers,
• in the Formula A-III, X is S or NH, R1 is directly bonded to X, and R1 is directly bonded to one of R2, R3, R4, and R5 to form a cyclic structure,
• in the Formula A-I, A-II, and A-III, two or more of R2, R3, R4, and R5 are connected to form a saturated or unsaturated alicyclic ring, alicyclic heterocycle, aromatic ring, or aromatic heterocycle, together with carbon atom(s).