Antibody molecules and uses thereof
AssigneeThe University Court of the University of Aberdeen
InventorsNeil Andrew Robert Gow, Fiona Marion Rudkin, Lars-Peter Erwig, Allan Jensen
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Abstract
This invention relates to recombinant human antibody molecules. The antibodies bind fungal antigens, for example from Candida spp. Human antibody encoding genes targeting clinically relevant Candida epitopes have been isolated from single B cells from carefully selected donors and screened with specified types of protein or cell wall extract. The panel of purified, fully human recombinant IgG1 mAbs generated displayed a diverse range of specific binding profiles and demonstrated efficacy in a disease model. The fully human mAbs and derivatives thereof have utility in the generation of diagnostics, therapeutics and vaccines.
Claims8
A method of treatment of a Candida infection comprising administering an anti-Candida antibody molecule to an individual in need thereof, wherein the antibody molecule is a whole antibody comprising a VH domain comprising:
- (i) a HCDR1 having the amino acid sequence of SEQ ID NO:
- 277;
- (ii) a HCDR2 having the amino acid sequence of SEQ ID NO:
- 279;
- and
- (iii) a HCDR3 having the amino acid sequence of SEQ ID NO:
- 281;
- and a VL domain comprising:
- (i) a LCDR1 having the amino acid sequence of SEQ ID NO:
- 284;
- (ii) a LCDR2 having the amino acid sequence of SEQ ID NO:
- 286;
- and
- (iii) a LCDR3 having the amino acid sequence of SEQ ID NO:
- 288.
Dependencies are inferred from the claim text.