Monoclonal antibody 14F5F6 or fragment thereof, that specifically recognizes herpes simplex virus 1 and 2
AssigneesPontificia Universidad Catolica De Chile, Fundación Copec Universidad Católica
InventorsAlexis Kalergis Parra, Susan Bueno Ramírez, Pablo Gonzalez Muñoz
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Abstract
The present invention refers to a new monoclonal antibody or fragment thereof, called 14F5F6, which specifically recognizes herpes simplex virus (HSV), in its two types, herpes simplex virus type 1 and herpes simplex virus type 2 (HSV-1 and HSV-2). Preferably, the antibody of the invention is useful for the development of methods for the diagnosis of herpes simplex virus infection, as well as for the production of pharmaceutical compositions intended for the treatment, protection and/or prophylaxis of infection specifically caused by HSV-1 and HSV-2.
Claims14
A monoclonal antibody or an antigen-binding fragment thereof that specifically recognizes herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2),
- wherein said antibody or the antigen-binding fragment thereof has a variable region of a heavy chain in which CDR1, CDR2, and CDR3 have amino acid sequences defined in SEQ ID No:3, SEQ ID No:4, and SEQ ID No:
- 5, respectively, and at the same time has a variable region of a light chain in which CDR1, CDR2 and CDR3 have amino acid sequences defined in SEQ ID No:6, SEQ ID No:7 and SEQ ID No:8, respectively.
A monoclonal antibody or an antigen-binding fragment thereof that specifically recognizes herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2), wherein said monoclonal antibody or the antigen-binding fragment thereof has a variable region of a heavy chain in which CDR1, CDR2 and CDR3 are encoded by sequences defined with SEQ ID No:11, SEQ ID No:12, and SEQ ID No:13, respectively, and has a variable region of a light chain in which CDR1, CDR2, and CDR3 are encoded by sequences defined with SEQ ID No:14, SEQ ID No:15, and SEQ ID No:
- 16, respectively.
Dependencies are inferred from the claim text.