Cell surface modification by coating with peptide amphiphiles (PAs)
AssigneeNorthwestern University
InventorsSlgirim Lee, Samuel I. Stupp, Lewis Fraser
Life of this patent
Estimating the term…
Abstract
Provided herein are peptide amphiphiles (PAs). In some embodiments, provided herein are targeting PAs comprising a PA backbone and a targeting moiety. In some embodiments, the peptide amphiphiles are assembled into nanofibers. In some embodiments, provided herein are cells coated with a targeting PA or a nanofiber comprising the same, and methods of use thereof.
Claims13
A cell comprising a plurality of peptide amphiphiles coating at least a portion of an outer surface of the cell, wherein each peptide amphiphile comprises a hydrophobic tail comprising an 8-24 carbon alkyl chain (C8-24), a structural peptide segment comprising V3A3 (SEQ ID NO:
- 6), a charged peptide segment comprising EE, EEE, or EEEE (SEQ ID NO:
- 4), and a targeting moiety comprising VHPKQH (SEQ ID NO:
- 1), Cyclo(1,12)PenITDGEATDSGC (SEQ ID NO:
- 18) (cLABL), or RDVLPGT (SEQ ID NO:
- 2), wherein the plurality of peptide amphiphiles coat at least 75% of the outer surface of the cell.
Dependencies are inferred from the claim text.