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US 12,247,050 B2Granted
α-sheet polypeptides and their use
AssigneeUniversity of Washington
InventorsValerie Daggett, Dylan Shea, Alissa Bleem
Life of this patent
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Abstract
Alpha-sheet polypeptide multimers, and polypeptides for making multimers, compositions and medical devices including them, and their use for treating and diagnosing amyloid diseases or amyloid-associated diseases are disclosed.
Claims25
An α-sheet polypeptide multimer, comprising:
- two monomeric α-sheet polypeptides that are covalently linked,
- wherein each monomeric α-sheet polypeptide comprises the amino acid sequence of rGeMnLsWmneyyGwTmNmKcGr (SEQ ID NO:25) or its reverse chiral counterpart,
- wherein residues in lower-case are D amino acids, residues in upper case are L amino acids, and G residues are achiral.
An α-sheet polypeptide comprising the amino acid sequence of
- rGeMnLsWmneyyGwTmNmKcGr (SEQ ID NO:25) or its reverse chiral counterpart,
- wherein residues in lower-case are D amino acids, residues in upper case are L amino acids, and G residues are achiral.
Dependencies are inferred from the claim text.