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US 12,247,047 B2Granted
Arnatar compounds and methods for enhanced cellular uptake
AssigneeArnatar Therapeutics, Inc
InventorsDerek Steiner, Xuehai Liang, Yangfeng Wang
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Abstract
This invention generally relates to the field of compounds and methods for enhanced cellular uptake. In particular, the invention relates to N-acetylgalactosamine compounds and their conjugates. Also provided are methods for the preparation of these molecules and possible uses thereof, in particular in medicine.
Claims8
A compound having the structure of formula (0a), (Ia) or (IIa):
- Wherein
- X is a hydroxy-protecting group or an H atom,
- Y is a hydroxy-protecting group, an H atom, a payload, or a solid support,
- Oligo represents a modified and/or unmodified oligonucleotide
- R1 is selected from any of hydroxy-protecting groups and H atom,
- R6 represents a hydroxy-protecting group, and
- R7 represents a moiety of formula (VI):
- wherein in R7
- R represents a solid support, an amino-protecting group, a hydroxy-protecting group,
- or an H atom,
- Z represents NH or O, and
- R8 represents a linear or branched alkylene having from 1 to 8 carbon atoms and/or a cycloalkylene having from 5 to 8 carbon atoms.
9 more elements
Dependencies are inferred from the claim text.