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US 12,247,012 B2Granted
Synthesis of nirogacestat
AssigneeSpringworks Therapeutics, Inc.
InventorsKristin Patterson, Mark Hatcher
Life of this patent
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Abstract
The present disclosures are directed to processes for synthesizing (S)-2-(((S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino)-N-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1H-imidazol-4-yl)pentanamide (“nirogacestat”).
Claims15
A process for preparing a composition comprising Compound 1 or a pharmaceutically acceptable salt thereof which is susceptible to oxidation that is substantially free of Compound 13
- comprising the steps of:
- i) dissolving Compound 11 in a solvent,
- ii) reacting Compound 9
- with 1,1′-carbonyldiimidazole to form Compound 10,
- and iii) combining Compound 10 with Compound 11 to form a composition comprising Compound 1 or a pharmaceutically acceptable salt thereof, where Compound 1 has the formula
2 more elements
Dependencies are inferred from the claim text.