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US 12,246,108 B2Granted
Mussel inspired nanocomposite adhesives for biomedical applications
AssigneeBoard of Regents, The University of Texas System
InventorsYi Hong, Kytai Nguyen, Philippe Zimmern, Jun Liao
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Abstract
A tissue adhesive composition comprises a biodegradable adhesive; nanoparticles; and a tissue regenerative agent. Methods of adhering tissue comprise applying a film of the tissue adhesive composition to a first surface of a first biological tissue; contacting a second surface of a second biological tissue with the first surface of the first biological tissue, wherein the film of the composition is positioned between and in contact with both the first surface and the second surface.
Claims17
A tissue adhesive composition comprising:
- a biodegradable adhesive;
- nanoparticles;
- and
- a tissue regenerative agent,
- wherein the nanoparticles are loaded with the tissue regenerative agent, and
- wherein the composition has a lap shear strength greater than 35 kPa when adhered to a biological tissue to tissue interface for 1 hour,
- wherein the biodegradable adhesive comprises a dopamine grafted alginate, polytripeptide (Gly-Tyr-Lys), Mussel Adhesive Protein (MAP), polyethylene glycol (PEG-DOPA), hyaluronic acid (HA) on Pluronic hydrogel, catechol-Ala-Ala-PEG (CAAPEG), poly ((Lys·HBr)x-(DOPA)y), deacetylated chitosan, oxidized and DOPA-functionalized dextran, PEG-dopamine-polycaprolactone (PCL), injectable citrate-based mussel-inspired bioadhesives iCMBAs, anti-bacterial and anti-fungal iCMBAs (AbAf iCs), click iCs, ethylene glycol acrylate methacrylate dopamine (EGAMA-DOPA), poly (dopamine-co-acrylate) (PDA), rfp-1 (MAP), light-activated, mussel protein-based bioadhesive (LAMBA), PEU (poly (CATyr-co-Leu)), PEU (poly (CA-Ser-co-Leu-co-PPG)), POEC-d (octanediol, PEO, citric acid, dopamine), DCTA (gelatin macromer, Fe3+, genipin), a polyester, 4-arm-PEG-DA, 4-arm-PEG-PBA, polypeptide-pluronic-polypeptide, or any combination thereof;
- wherein the biodegradable adhesive is present in a concentration of 1 to 40 wt. % and comprises a polymer having a weight average molecular weight of 20,000-200,000;
- wherein the nanoparticles comprise poly (lactic acid) (PLA), poly (glycolic acid) (PGA), poly (lactide-co-glycolide) (“PLGA”), poly (lactide-co-glycolide) N-hydroxysuccinimide (“PLGA-NHS”), poly (lactide-co-glycolide) polydopamine (“PLGA-Dopa”), polydopamine, hyaluronic acid-dopamine, silica, poly-(ethylene glycol) (PEG), poly (acryl amide) (PAA), poly (vinyl pyrrolidone) (PVP), poly (caprolactone) (PCL), chitosan, poly-alkyl-cyano-acrylates (PAC), gelatin or any combination thereof;
- wherein the nanoparticles have an average particle size in any dimension of 50 nm to 500 nm;
- wherein the tissue regenerative agent comprises a cell recruitment agent, a tissue growth factor, a protein, a microRNA, an exosome, or any combination thereof;
- wherein the tissue regenerative agent comprises a cell recruitment agent;
- and
- wherein the cell recruitment agent is stromal cell derived factor-1 alpha (“SDF-1α”).
11 more elements
A tissue adhesive composition comprising:
- a biodegradable adhesive;
- nanoparticles;
- and
- a tissue regenerative agent,
- wherein the nanoparticles are loaded with the tissue regenerative agent, and wherein the composition has a lap shear strength greater than 35 kPa when adhered to a biological tissue to tissue interface for 1 hour,
- wherein the biodegradable adhesive is present in a concentration of 1 to 40 wt. % and comprises a polymer having a weight average molecular weight of 20,000-200,000;
- wherein the biodegradable adhesive comprises a dopamine grafted alginate;
- wherein the nanoparticles have an average particle size in any dimension of 50 nm to 500 nm;
- wherein the nanoparticles comprise poly (lactide-co-glycolide) (“PLGA”);
- and
- wherein the tissue regenerative agent comprises stromal cell derived factor-1 alpha (“SDF-1α”).
8 more elements
Dependencies are inferred from the claim text.