Recombinant herpes simplex virus having modified glycoprotein gH for retargeting and use thereof
AssigneeGencellmed Inc.
InventorsHeechung Kwon, Hyunjung Baek
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Abstract
Proposed are a recombinant herpes simplex virus having a modified glycoprotein gH for retargeting and the use thereof. Particularly, the recombinant herpes simplex virus is capable of infecting a target cell having a target molecule to which a cell-targeting domain specifically recognizes and binds due to the presence of the cell-targeting domain in the glycoprotein gH thereof, and is thus useful for anticancer therapy or gene therapy.
Claims18
A recombinant herpes simplex virus, configured such that a cell-targeting domain, which specifically recognizes and binds to a target molecule of a target cell, is inserted and fused into a glycoprotein gH,
- wherein the cell-targeting domain is inserted and fused into a position between the region of amino acids 29 and 30 in the amino acid sequence of the gH glycoprotein comprising SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.