Medical adhesives for quick release of antimicrobials
AssigneeAvery Dennison Corporation
InventorsNeal Carty, Jilin Zhang
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Abstract
Provided herein are adhesive compositions comprising: 1) at least one adhesive of an alcohol-functionalized acrylic adhesive, an alcohol-functionalized silicone adhesive, a carboxyl-functionalized acrylic adhesive, and a carboxyl-functionalized silicone adhesive, 2) at least one phase-separated hydrophilic material, and 3) at least one bioactive compound. At least one bioactive compound may comprise an antimicrobial agent. The adhesive compositions can quickly release an antimicrobial agent and cause the rapid onset of antimicrobial effects. Also provided are adhesive products and methods using the disclosed adhesive composition.
Claims30
An adhesive composition comprising:
- at least one adhesive, wherein the at least one adhesive is an alcohol-functionalized acrylic adhesive;
- at least one phase-separated hydrophilic material selected from the group consisting of silicon dioxide, titanium dioxide, and combinations thereof;
- and
- at least one bioactive compound comprising an antimicrobial agent,
- wherein
- a concentration of the at least one bioactive compound in the adhesive composition ranges from about 1 wt % to about 10 wt %;
- wherein a concentration of the at least one phase-separated hydrophilic material in the adhesive composition ranges from about 7 wt % to about 15 wt %;
- wherein a concentration of the at least one adhesive in the at least one adhesive composition ranges from about 80 wt % to about 90 wt %, and
- wherein the adhesive composition has a release rate of the at least one bioactive compound into water, and wherein the release rate is at least about 50 μg/cm2 within 90 minutes of contact of the adhesive composition with water.
A method for producing an adhesive composition, the method comprising:
- providing:
- 1) at least one adhesive wherein the at least one adhesive is an alcohol-functionalized acrylic adhesive, 2) at least one phase-separated hydrophilic material selected from the group consisting of silicon dioxide, titanium dioxide, and combinations thereof, and 3) at least one bioactive compound comprising an antimicrobial agent;
- and
- combining the at least one adhesive, the at least one phase-separated hydrophilic material, and the at least one bioactive compound to produce the adhesive composition,
- wherein
- a concentration of the at least one bioactive compound in the adhesive composition ranges from about 1 wt % to about 10 wt %;
- wherein a concentration of the at least one phase-separated hydrophilic material in the adhesive composition ranges from about 7 wt % to about 15 wt %;
- wherein a concentration of the adhesive in the adhesive composition ranges from about 80 wt % to about 90 wt %, and
- wherein the adhesive composition has a release rate of the at least one bioactive compound into water, and wherein the release rate is at least about 50 μg/cm2 within 90 minutes of contact of the adhesive composition with water.
Dependencies are inferred from the claim text.