Omega-alicyclic tunicamycins and analogs
AssigneeThe United States of America as represented by the Secretary of Agriculture
InventorsNeil P. Price, Michael A. Jackson, Trina M. Hartman, John P. Bannantine
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Abstract
The invention relates to new tunicamycin structures comprising N-acyl groups metabolically integrated into the terminus of the TUN via the Streptomyces branched chain fatty acid pathways and variants thereof, and methods of preparing such new tunicamycin structures. The invention further relates to antibacterial compositions comprising such new tunicamycin structures, and methods for using such antibacterial compositions for killing Gram-positive bacteria.
Claims10
An N-acyl-tunicamycin variant of
- wherein n is independently any integer from 7 to 13;
- and
- X is a tert-butyl-branched chain, a cyclopropane, a cyclobutane, a cyclopentane, a cyclohexane, a cycloheptane, an unsaturated cyclohexene, or an unsaturated cyclopentene.
An N-acyl-tunicamycin variant of formula 2
- wherein n is independently any integer from 7 to 13;
- and
- X is a tert-butyl-branched chain, a cyclopropane, a cyclobutane, a cyclopentane, a cyclohexane, a cycloheptane, an unsaturated cyclohexene, or an unsaturated cyclopentene.
Dependencies are inferred from the claim text.