Recombinant microorganisms and uses therefor
AssigneeLanzaTech, Inc.
InventorsNicholas Alexander Fackler, Sean Dennis Simpson, Michael Koepke, Stephanie Rhianon Jones
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Abstract
The disclosure provides genetically engineered C1-fixing microorganisms capable of producing nanobodies. Additionally, the disclosure provides engineered microorganisms comprising one or more disrupted genes to strategically divert carbon flux away from nonessential or undesirable products towards products and/or co-products of interest. The disclosure enables co-production of useful chemicals from gaseous substrates.
Claims8
A genetically engineered C1-fixing microorganism capable of co-producing at least one target product and a nanobody comprising an exogenous nucleic acid encoding a nanobody gene, wherein the genetically engineered C1-fixing microorganism has improved carbon flux through acetoacetyl-CoA compared to a parental microorganism, wherein the nanobody gene is VHH-72 SARS Cov2.
Dependencies are inferred from the claim text.