Peptide therapeutics for treating Alzheimer's disease and related conditions
AssigneeThe Board of Regents of the University of Oklahoma
InventorsAnne Kasus-Jacobi, Heloise Anne Pereira, Amanda J. Stock
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Abstract
Peptide compounds derived from cathepsin G (CG), neutrophil elastase (NE), and cationic antimicrobial protein of 37 kDa (CAP37), and methods of their use in inhibiting and/or reversing polymerization of amyloid β peptide into oligomers and/or fibrils, and/or disaggregating amyloid β plaques, and methods of use of the peptide compounds in treatments of, for example, Alzheimer's disease, cerebral amyloid angiopathy, dementia, and/or neuroinflammation, and/or symptoms thereof are disclosed.
Claims18
A peptide compound comprising a peptide comprising amino acid sequence SEQ ID NO:
- 20.
A peptide compound comprising a peptide comprising amino acid sequence SEQ ID NO:
- 44.
A peptide compound comprising a peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:
- 43 and SEQ ID NO:
- 15.
Dependencies are inferred from the claim text.