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US 12,241,080 B2Granted
Bacteriophage-based artificial viruses for human genome remodeling
AssigneeThe Catholic University of America
InventorsVenigalla B. Rao, Jingen Zhu
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Abstract
Described is an “artificial virus” (AV) programmed with biomolecules that can enter human cells and carry out precise human genome modification. The AVs comprise: at least one viral vector, such as bacteriophage T4; at least one therapeutic molecule, such as DNA, RNA, protein and their complex; and a lipid coating. Also described is a method of human genome modification, using such an AV, and a method of program such an AV.
Claims6
A human genome remodeling artificial virus (AV) comprising:
- a T4 capsid;
- a Cas9 protein;
- at least one RNA;
- at least one DNA;
- and
- a lipid coating,
- wherein the DNA is packaged inside the T4 capsid;
- wherein the RNA is selected from the group consisting of a mRNA, a siRNA, and a gRNA,
- wherein the lipid coating comprises at least one cationic lipid.
6 more elements
Dependencies are inferred from the claim text.