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US 12,240,915 B2Granted
Chimeric antigen receptor cells for treating solid tumor
AssigneesInnovative Cellular Therapeutics Holdings, Ltd., Innovative Cellular Therapeutics, Inc.
InventorsLei Xiao, He Sun, Zhiyuan Cao, Wensheng Wang, Chengfei Pu, Li Mao
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Abstract
The compositions and methods described herein are directed to treating solid tumor using CAR T therapy. The compositions include CAR comprising an extracellular domain that binds a siglec protein or a receptor that binds the peptide hormone kisspeptin.
Claims19
An antibody that binds ACPP, wherein the antibody comprises
- (a) a light chain variable region (LVR) comprising amino acid sequence SEQ ID NO:
- 82 and a heavy chain variable region (HVR) comprising amino acid sequence SEQ ID NO:
- 83;
- (b) an LVR comprising amino acid sequence SEQ ID NO:
- 84 and an HVR comprising amino acid sequence SEQ ID NO:
- 85;
- (c) an LVR comprising amino acid sequence SEQ ID NO:
- 86, and an HVR comprising amino acid sequence SEQ ID NO:
- 87;
- or
- (d) an LVR comprising amino acid sequence SEQ ID NO:
- 88 and an HVR comprising amino acid sequence SEQ ID NO:
- 89.
10 more elements
Dependencies are inferred from the claim text.