Bispecific antibodies specific for OX40
AssigneeHoffmann-La Roche Inc.
InventorsMaria Amann, Peter Bruenker, Christina Claus, Claudia Ferrara Koller, Sandra Grau-Richards, Ralf Hosse, Christian Klein, Viktor Levitski, Pablo Umana
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Abstract
The invention relates to novel bispecific antigen binding molecules, comprising (a) at least one moiety capable of specific binding to a target cell antigen, (b) at least one moiety capable of specific binding to a costimulatory TNF receptor family member, and (c) a Fc domain composed of a first and a second subunit capable of stable association, and to methods of producing these molecules and to methods of using the same.
Claims20
An antibody or antibody fragment thereof that specifically binds to OX40, wherein said antibody or fragment thereof comprises:
- (a) a heavy chain variable domain (VH) comprising:
- (i) a CDR-H1 comprising the amino acid sequence of SEQ ID NO:2;
- (ii) a CDR-H2 comprising the amino acid sequence of SEQ ID NO:4;
- (iii) a CDR-H3 comprising the amino acid sequence of SEQ ID NO:6;
- and
- (b) a light chain variable domain (VL) comprising:
- (i) a CDR-L1 comprising the amino acid sequence of SEQ ID NO:
- 13;
- (ii) a CDR-L2 comprising the amino acid sequence of SEQ ID NO:
- 16;
- and
- (iii) a CDR-L3 comprising the amino acid sequence of SEQ ID NO:19.
An antibody that specifically binds to OX40, comprising:
- (a) a light chain comprising the amino acid sequence of SEQ ID NO:182;
- and
- (b) a heavy chain comprising the amino acid sequence of SEQ ID NO:
- 183.
Dependencies are inferred from the claim text.