Decoy cytokine receptor
AssigneesNational University of Singapore, Singapore Health Services Pte Ltd
InventorsStuart Alexander Cook, Sebastian Schaefer
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Abstract
An IL-11 binding receptor capable of binding to IL-11 and inhibiting IL-11 mediated signalling is disclosed. Also disclosed are compositions comprising the IL-11 binding receptor and methods using the IL-11 binding receptor.
Claims12
An isolated nucleic acid encoding (i) an amino acid sequence having at least 90% sequence identity to the cytokine binding module (CBM) of gp130 as set forth in SEQ ID NO:
- 19, and (ii) an amino acid sequence having at least 90% sequence identity to the cytokine binding module (CBM) of IL-11Ra as set forth in SEQ ID NO:
- 20.
A vector comprising a nucleic acid encoding (i) an amino acid sequence having at least 90% sequence identity to the cytokine binding module (CBM) of gp130 as set forth in SEQ ID NO:
- 19, and (ii) an amino acid sequence having at least 90% sequence identity to the cytokine binding module (CBM) of IL-11Rα as set forth in SEQ ID NO:
- 20.
An isolated nucleic acid encoding an amino acid sequence having at least 90% sequence identity to the sequence of SEQ ID NO:1 or SEQ ID NO:2.
Dependencies are inferred from the claim text.