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AssigneeQilu Pharmaceutical Co., Ltd.
InventorsYue Yu, Guijiang Wang, Jiulin Wang, Zhenming An, Qingmin Wang, Daoyuan Li, Chuanlei Liu, Feifei Liu, Huanlan Zheng, Peng Wan, Bo Xie
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Provided is a composition comprising aflibercept and a variant thereof, wherein the variant is a truncation variant with a truncated VEGF binding portion of aflibercept, and wherein the content of the truncation variant is less than or equal to about 20% by mass percentage. Also provided is a pharmaceutical formulation comprising the composition. Further, provided are a method for detecting the variant and use of the variant in quality inspection or quality control of an aflibercept-containing product.
A composition comprising aflibercept and a variant thereof, wherein the variant is a truncation variant with a truncated VEGF binding portion of aflibercept, and said variant comprises a first peptide chain with an amino acid sequence set forth in SEQ ID NO:
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