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US 12,240,820 B2Granted
Barbituric acid derivatives, their preparation and use thereof as leukocyte transmigration inhibitors and for treating inflammatory diseases, autoimmune diseases and cancer
AssigneesBar-Ilan University, University of Geneva, Geneva University Hospitals
InventorsArie Lev Gruzman, Paul Bradfield, Tamar Getter, Beat Imhof, Thomas Matthes, Hanoch Senderowitz
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Abstract
Provided herein are novel barbituric acid derivatives, their synthesis and use thereof in blocking leukocyte transmigration. The novel barbituric acid derivatives are useful for the treatment of disorders associated with leukocyte transmigration, such as for example inflammatory diseases and disorders, autoimmune diseases and disorders, and cancers.
Claims15
A compound of general Formula (Ib):
- wherein
- Z is absent;
- and
- R5 is hydrogen, linear alkyl, branched alkyl, linear alkenyl or branched alkenyl, wherein each of the alkyl and the alkenyl may be unsubstituted or substituted with one, two, or three substituents selected from the group consisting of halo, nitro, cyano and amino;
- and stereoisomers, enantiomers and tautomers thereof, pharmaceutically acceptable salts thereof and mixtures thereof,
- wherein the bonds to the barbituric acid moiety and to the linking group —O—CH2—are located meta to each other.
3 more elements
Dependencies are inferred from the claim text.