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US 12,240,801 B2Granted
Method of synthesis and purification of citrulline
AssigneeAsklepion Pharmaceuticals, LLC
InventorsJames Alan Bull, Holger Christian Fischer, Karl Juergen Kaiser, Bette Monnot-Chase
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Abstract
This invention provides for synthesis of citrulline from a transition metal complex of ornithine using cyanate to derivatize the terminal amino group of ornithine. The invention also provides improved methods for purification of citrulline produced by reaction of cyanate with ornithine via the steps of reprecipitation of copper complex of citrulline, removal of the complexing metal by sulfide precipitation, activated carbon adsorption and antisolvent crystallization.
Claims4
A method of adding a terminal carbamido group to an alpha amino acid comprising:
- (a) obtaining an alpha-amino acid having a terminal amine complexed with copper in aqueous solution;
- (b) reacting the alpha amino acid having a terminal amine with a cyanate;
- and
- (c) recovering a carbamido derivative of the alpha-amino acid complexed to copper as a precipitate.
1 more element
Dependencies are inferred from the claim text.