Peptides and antibodies for the removal of biofilms
AssigneeResearch Institute At Nationwide Children's Hospital
InventorsLauren O. Bakaletz, Steven D. Goodman
Life of this patent
Estimating the term…
Abstract
This disclosure provides isolated or recombinant polypeptides that are useful to vaccinate individuals suffering from chronic/recurrent biofilm disease or as a therapeutic for those with an existing infection. The individual's immune system will then naturally generate antibodies which prevent or clear these bacteria from the host by interfering with the construction and or maintenance of a functional protective biofilm. Alternatively, antibodies to the polypeptides can be administered to treat or prevent infection. Bacteria that are released from the biofilm by our technology are more readily cleared by the remainder of the host's immune system.
Claims18
A composition comprising one or more of a preservative, an adjuvant, or a stabilizer;
- and an isolated polynucleotide encoding one or more polypeptides selected from:
- (i)
- SEQ ID NO. 13
- a polypeptide consisting of (RPGRNPKTGDVVPVSARRVV);
- (ii)
- SEQ ID NO. 16
- a polypeptide consisting of (RGFGSFSLHHRQPRLGRNPK);
- or
- (iii)
- SEQ ID NO. 17
- a polypeptide consisting of (FSLHHRQPRLGRNPKTGDSV).
A composition comprising a vector comprising an isolated, non-naturally occurring polynucleotide encoding one or more polypeptides selected from:
- (i)
- SEQ ID NO. 13
- a polypeptide consisting of (RPGRNPKTGDVVPVSARRVV);
- (ii)
- SEQ ID NO. 16
- a polypeptide consisting of (RGFGSFSLHHRQPRLGRNPK);
- or
- (iii)
- SEQ ID NO. 17
- a polypeptide consisting of (FSLHHRQPRLGRNPKTGDSV),
- and one or more of a preservative, an adjuvant, or a stabilizer.
A composition comprising an isolated host cell comprising an isolated, non-naturally occurring polynucleotide encoding one or more polypeptides selected from:
- (i)
- SEQ ID NO. 13
- a polypeptide consisting of (RPGRNPKTGDVVPVSARRVV);
- (ii)
- SEQ ID NO. 16
- a polypeptide consisting of (RGFGSFSLHHRQPRLGRNPK);
- or
- (iii)
- SEQ ID NO. 17
- a polypeptide consisting of (FSLHHRQPRLGRNPKTGDSV),
- and one or more of a preservative, an adjuvant, or a stabilizer.
Dependencies are inferred from the claim text.