Adhesive device for biomedical applications and methods of use thereof

A method of adhering a first surface and a second surface comprising:

• applying an adhesive device to at least a portion of at least one of the first and second surfaces;
• and bringing at least a portion of the first and second surfaces into contact with each other and/or bringing at least a portion of the first and second surfaces into contact with the adhesive device
• wherein the device comprises:
• a support;
• and
• a water insoluble adhesive on at least one bonding site on a surface of the support, the adhesive comprising:
• a compound of structure 1
• wherein
• the compound is water insoluble;
• the compound has a Tg lower than 25° C.;
• B is a branched or unbranched oligomer derived from a polyester, polyether, polyalkylene glycol, polysilicone or polycarbonate with a MW<10,000 q/mol;
• Linker L is an urethane, urea bond, or amide bond;
• Linker L′ is an urethane or urea bond;
• A is a chain extender of Mw≤3000 q/mol comprising substituted or unsubstituted alkyl, cycloalkyl and/or aromatic groups;
• W is a terminal adhesive selected from an adhesive benzene-1,2-diol derivative or an adhesive benzene-1,2,3-triol derivative;
• m is 0 or 1;
• and
• n is 0, 1, 2, 3 or 4;
• or
• a cross-linked polymer produced by cross-linking compounds of structure 1.

A method of stabilizing a surface comprising applying an adhesive device to the surface

• wherein the device comprises:
• a support;
• and
• a water insoluble adhesive on at least one bonding site on a surface of the support, the adhesive comprising:
• a compound of structure 1
• wherein
• the compound is water insoluble;
• the compound has a Tg lower than 25° C.;
• B is a branched or unbranched oligomer derived from a polyester, polyether, polyalkylene glycol, polysilicone or polycarbonate with a MW<10,000 q/mol;
• Linker L is an urethane, urea bond, or amide bond;
• Linker L′ is an urethane or urea bond;
• A is a chain extender of Mw s 3000 g/mol comprising substituted or unsubstituted alkyl, cycloalkyl and/or aromatic groups;
• W is a terminal adhesive selected from an adhesive benzene-1,2-diol derivative or an adhesive benzene-1,2,3-triol derivative;
• m is 0 or 1;
• and
• n is 0, 1, 2, 3 or 4;
• or
• a cross-linked polymer produced by cross-linking compounds of structure 1.