Vaccination with replicon particles and oil adjuvant
AssigneeIntervet Inc.
InventorsMark A. Mogler, Erin Strait, Ruud Philip Antoon Maria Segers
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Abstract
The present invention relates to vaccination against animal pathogens using alphavirus-replicon RNA particles and oil adjuvants. To a vaccine, and a kit of parts comprising the replicon particles and the oil adjuvant. Also to methods and uses of making and using the vaccine and the components of the kit.
Claims19
A vaccine comprising an alphavirus RNA replicon particle encoding an antigen originating from an animal pathogen, wherein the vaccine also comprises an oil adjuvant which comprises a mineral oil and a non-mineral oil, wherein the mineral oil is a liquid paraffin oil and wherein the non-mineral oil is Vitamin E acetate.
A kit comprising at least two containers, wherein at least one container comprises an alphavirus RNA replicon particle encoding an antigen originating from an animal pathogen, and at least one container comprises an oil adjuvant, which comprises a mineral oil and a non-mineral oil;
- wherein the mineral oil is a liquid paraffin oil and wherein the non-mineral oil is Vitamin E acetate.
Dependencies are inferred from the claim text.