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US 12,234,492 B2Granted
Microorganism for fermentative production of 2-phenylethanol from gaseous substrates
AssigneeLanzaTech, Inc.
InventorsFungmin Liew, Michael Koepke, Shilpa Nagaraju, Audrey Harris
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Abstract
Disclosed herein are improved methods for production of 2-phenylethanol by microbial fermentation of substrates comprising carbon monoxide and/or carbon dioxide and further disclosed are genetically modified microorganisms for use in such methods that alleviate dependence on natural and petrochemical processes.
Claims13
A C1-fixing microorganism that produces 2-phenylethanol, wherein the microorganism comprises:
- (a) a heterologous enzyme that converts phenylpyruvate to phenylacetaldehyde, wherein the enzyme is a decarboxylase;
- and
- (b) a heterologous enzyme that converts phenylacetaldehyde to 2-phenylethanol, wherein the enzyme is a phenylacetaldehyde;
- wherein the heterologous enzyme in (a) is encoded by a nucleic acid with at least 90% identity to SEQ ID NO:
- 1, 2, or 4;
- and the heterologous enzyme in (b) is encoded by a nucleic acid with at least 90% identity to SEQ ID NO:
- 3, 5, 6, 7, 8, or 9;
- and wherein the microorganism is a Wood-Ljungdahl microorganism.
5 more elements
Dependencies are inferred from the claim text.