Compositions and methods for therapeutic delivery
AssigneeGenVivo, Inc.
InventorsBrile Chung, Cecilia Roh, Robert G. Johnson, Jr.
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Abstract
Described herein are compositions comprising a recombinant retroviral vector for delivering a therapeutic comprising a nucleic acid construct comprising a polynucleotide sequence encoding an interleukin or a subunit thereof. Also described herein are methods of using the composition comprising a recombinant retroviral vector described herein for delivering a therapeutic comprising a nucleic acid construct comprising a polynucleotide sequence encoding an interleukin or a subunit thereof to a subject.
Claims17
A method of treating cancer in a subject, comprising administering to the subject a first murine leukemia virus recombinant retroviral vector comprising a nucleic acid construct comprising a viral promoter operatively linked to a first polynucleotide sequence encoding a P40 subunit of Interleukin-12 (IL-12), a second polynucleotide sequence encoding a P35 subunit of IL-12, and a third polynucleotide sequence between the first and second polynucleotide sequences, wherein the third polynucleotide sequence encodes a cleavage site that facilitates cleavage between P40 subunit and P35 subunit, wherein route of the administering to the subject is selected from the group consisting of intravenous and intra-arterial routes, and wherein the recombinant retroviral vector induces a cell kill activity in the subject, thereby treating cancer in said subject.
Dependencies are inferred from the claim text.