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US 12,234,473 B2Granted
CD8 polypeptides, compositions, and methods of using thereof
AssigneeImmatics US, Inc.
InventorsGagan Bajwa, Mamta Kalra, Melinda Mata
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Abstract
The present disclosure relates to T cells capable of co-expressing T cell receptors (“TCR”) together with CD8 polypeptides and the use thereof in adoptive cellular therapy. The present disclosure further provides for modified CD8 sequences, vectors, and associated methods thereof.
Claims12
A nucleic acid encoding a T-cell receptor (TCR) comprising an α chain and a β chain and a CD8 α chain,
- wherein the CD8 α chain comprises the amino acid sequence with at least 98% identity to SEQ ID NO:
- 5.
A nucleic acid encoding a CD8 α chain comprises the amino acid sequence with at least 98% identity to SEQ ID NO:
- 5.
Dependencies are inferred from the claim text.