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US 12,234,295 B2Granted
Chimeric transmembrane protein comprising antibody dimerization domains and a type I cytokine receptor endodomain, encoding nucleic acids thereof and methods of use thereof
AssigneeAutolus Limited
InventorsMartin Pulé, Shaun Cordoba, Matteo Righi, James Sillibourne, Shimobi Onuoha, Simon Thomas
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Abstract
The present invention provides a chimeric cytokine receptor (CCR) comprising: (i) an exodomain which binds to a ligand selected from a tumour secreted factor, a chemokine and a cell-surface antigen; and (ii) a cytokine receptor endodomain.
Claims22
A chimeric transmembrane protein comprising:
- (i) a first polypeptide which comprises
- (a) a first dimerization domain comprising the dimerization portion of an antibody heavy chain constant domain (CH), and
- (b) a first chain of a Type I cytokine receptor endodomain;
- and
- (ii) a second polypeptide which comprises
- (a) a second dimerization domain comprising the dimerization portion of an antibody light chain constant domain (CL), which dimerizes with the first dimerization domain, and
- (b) a second chain of a Type I cytokine receptor endodomain;
- wherein the first and second polypeptides spontaneously dimerize.
5 more elements
A nucleic acid construct which comprises
- (i) a first nucleic acid comprising a nucleic acid sequence encoding a first polypeptide which comprises:
- (a) an antibody heavy chain constant domain (CH) and
- (b) a first chain of a Type I cytokine receptor endodomain;
- and
- (ii) a second nucleic acid comprising a nucleic acid sequence encoding a second polypeptide which comprises:
- (a) an antibody light chain constant domain (CL) and
- (b) a second chain of the Type I cytokine-receptor endodomain.
4 more elements
A kit which comprises:
- (i) a first vector comprising a nucleic acid sequence encoding a first polypeptide which comprises
- (a) an antibody heavy chain constant domain (CH), and
- (b) a first chain of a Type I cytokine receptor endodomain;
- and
- (ii) a second vector comprising a nucleic acid sequence encoding a second polypeptide which comprises
- (a) an antibody light chain constant domain (CL), and
- (b) a second chain of a Type I cytokine receptor endodomain.
4 more elements
Dependencies are inferred from the claim text.