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US 12,234,261 B2Granted
Hepatitis B vaccines and uses of the same
AssigneePrecigen, Inc.
InventorsDouglas E. Brough, Cheryl G. Bolinger, Ramya Yarlagadda, Vinodhbabu Kurella, Prabakaran Ponraj, Simon Metenou, Kuan-Fu Ding
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Abstract
Provided herein are engineered hepatitis B virus (HBV) molecular vaccine constructs. Vaccine constructs can also include ligand-inducible engineered gene switch systems for modulating expression of heterologous genes, such as a cytokines, in host cells.
Claims16
A polypeptide construct comprising:
- (a) (i) an HBV Pol domain consisting of SEQ ID NO:
- 99, and (ii) at least one additional domain selected from:
- an HBV Envelope domain consisting of SEQ ID NO:
- 100;
- an HBV Core domain consisting of SEQ ID NO:
- 101;
- and an HBx domain consisting of SEQ ID NO:
- 98;
- or
- (b) (i) an ankyrin-like repeat domain, and (ii) an HBV polypeptide.
7 more elements
Dependencies are inferred from the claim text.