Compounds as nuclear transport modulators and uses thereof

A compound having the structure of Formula (I′) or Formula (II′):

• or a pharmaceutically acceptable salt, wherein,
• R1 is selected from —C(═O)—R2, a 3- to 6-membered heterocycloalkyl, and a 5- to 10-membered heteroaryl, optionally substituted with one or more substituents selected from deuterium, —OH, —SH, —NO2, halogen, amino, cyano, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, C1-12 alkoxy, C1-12 haloalkyl, C1-12 haloalkoxy, and C1-12 alkylsulfanyl;
• and
• R2 is selected from C1-6 alkyl, C3-6 cycloalkyl, and a 3- to 6-membered heterocycloalkyl, optionally substituted with one or more substituents selected from halogen, amino, cyano, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, C1-12 alkoxy, C1-12 haloalkyl, C1-12 haloalkoxy, and C1-12 alkylsulfanyl.