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US 12,234,210 B2Granted
Synthesis of nirogacestat
AssigneeSpringworks Therapeutics, Inc.
InventorsKristin Patterson, Mark Hatcher
Life of this patent
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Abstract
The present disclosures are directed to processes for synthesizing (S)-2-(((S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino)-N-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1H-imidazol-4-yl)pentanamide (“nirogacestat”).
Claims4
A composition comprising 98.0% to 99.9% by weight of Compound 1 or a salt thereof prepared by a process comprising the steps of combining Compound 10
- with Compound 11
- to form Compound 1, and optionally treating Compound 1 with an acid in a solvent to form a salt of Compound 1
- wherein the composition comprises at least one of:
- (a) 0.7% to 0.01% by weight of Compound 2 having the formula
- or a pharmaceutically acceptable salt thereof,
- (b) 0.7% to 0.01% by weight of Compound 3 having the formula
- or a pharmaceutically acceptable salt thereof, or
- (c) 0.7% to 0.01% by weight of Compound 4 having the formula
- or a pharmaceutically acceptable salt thereof.
6 more elements
Dependencies are inferred from the claim text.