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US 12,234,205 B1Granted
Sulfonylhydrazide derivatives as anticancer agents
AssigneeKing Saud University
InventorsFatmah Ali S. Alasmary, Moustafa E. El-Araby, Linah Saad N. Alqahtani, Amr M. El-Araby
Life of this patent
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Abstract
Novel sulfonylhydrazide derivatives, a method of synthesizing said compounds, a pharmaceutical composition comprising said compounds and a suitable carrier, and a method of using the compounds. The sulfonylhydrazide derivative compounds, identified as FAAH inhibitors, are useful as anticancer and/or antitumor agents.
Claims8
A compound having the formula I:
- or a pharmaceutically acceptable salt, ester, stereoisomer, or solvate thereof, wherein:
- R is a direct bond, —CH2, or —CH2(Br);
- Ar is an optionally substituted phenyl, pyridine, naphthalene, or thiophene being optionally substituted with one or more substituents selected from the group consisting of hydrogen, bromine, COCH3, NO2, CF3, OCH3, methyl, isopropyl, and a second optionally substituted phenyl;
- wherein the second optionally substituted phenyl is substituted with a hydrogen, methyl, or methoxy.
1 more element
A compound selected from the group consisting of:
- 4-acetyl-N′-(2-(4-isobutylphenyl)propanoyl)benzenesulfonohydrazide (1);
- N′-(2-(4-isobutylphenyl) propanoyl)-4-methylbenzene sulfonohydrazide (2);
- N′-(2-(4-isobutylphenyl) propanoyl)-2-nitrobenzenesulfonohydrazide (3);
- N′-(2-(4-isobutylphenyl)propanoyl)naphthalene-2-sulfonohydrazide (4);
- N′-(2-(4-isobutylphenyl) propanoyl)-2, 4, 6 triisopropyl benzene sulfonohydrazide (5);
- 1-bromo-N′-(2-(4-isobutylphenyl) propanoyl)-1-phenylmethane sulfonohydrazide (6);
- N′-(2-(4-isobutylphenyl) propanoyl)-3-(trifluoromethyl) benzene sulfonohydrazide (7);
- N′-(2-(4-isobutylphenyl) propanoyl)-4-(trifluoromethyl) benzene sulfonohydrazide (8);
- N′-(2-(4-isobutylphenyl) propanoyl) benzenesulfonohydrazide (9);
- N′-(2-(4-isobutylphenyl) propanoyl)-[1, 1′-biphenyl]-4-sulfonohydrazide (10);
- N′-(2-(4-isobutylphenyl) propanoyl)-4′-methyl-[1, 1′-biphenyl]-4-sulfonohydrazide (11);
- N′-(2-(4-isobutylphenyl) propanoyl)-4′-methoxy-[1, 1′-biphenyl]-4sulfonohydrazide (12);
- 4-Bromo-N′-(2-(4-isobutylphenyl)propanoyl)benzenesulfonohydrazide (13);
- N′-(2-(4-isobutylphenyl) propanoyl)-3, 4-dimethoxybenzene sulfonohydrazide (14);
- N′-(2-(4-isobutylphenyl)propanoyl)thiophene-2-sulfonohydrazide (15);
- 5-bromo-N′-(2-(4-isobutylphenyl) propanoyl) thiophene-2-sulfonohydrazide (16);
- N′-(2-(4-isobutylphenyl)propanoyl)-5-methylthiophene-2-sulfonohydrazide (17);
- N′-(2-(4-isobutylphenyl)propanoyl)pyridine-3-sulfonohydrazide (18);
- N′-(2-(4-isobutylphenyl)propanoyl)-6-(trifluoromethyl)pyridine-3sulfonohydrazide (19);
- N′-(2-(4-isobutylphenyl)propanoyl)-1-phenylmethanesulfonohydrazide (20);
- and
- a pharmaceutically acceptable salt, ester, stereoisomer, or solvate thereof.
19 more elements
Dependencies are inferred from the claim text.