Synthetic methods of preparing esketamine
AssigneeJanssen Pharmaceutica NV
InventorCheng Yi Chen
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Abstract
The present invention is directed to methods for the asymmetric synthesis of esketamine. The present invention is further directed to key intermediates in the asymmetric esketamine synthesis. In one embodiment, the invention is an asymmetric synthesis of esketamine comprising the conversion of (S)-2′-chloro-2-methoxy-3,4,5,6-5 tetrahydro-[1, 1′-biphenyl]-3-yl carbamate to (S)-2′-chloro-1-isocyanato-6-methoxy-1,2,3,4-tetrahydro-1,1′-biphenyl.
Claims9
An asymmetric synthesis of esketamine, D3-esketamine, or (S)-norketamine comprising
- conversion of (S)-2′-chloro-2-methoxy-3,4,5,6-tetrahydro-[1,1′-biphenyl]-3-yl carbamate to (S)-2′-chloro-1-isocyanato-6-methoxy-1,2,3,4-tetrahydro-1,1′-biphenyl
A compound which is (S)-2′-chloro-2-methoxy-3,4,5,6-tetrahydro-[1,1′-biphenyl]-3-yl carbamate
A compound which is (S)-2′-chloro-1-isocyanato-6-methoxy-1,2,3,4-tetrahydro-1,1′-biphenyl
Dependencies are inferred from the claim text.