Method and system for solventless calibration of volatile or semi-volatile compounds
AssigneeThe United States of America as represented by the Secretary of the Air Force
InventorsMitchell H Rubenstein, Patrick Lewis
Life of this patent
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Abstract
A system for solventless calibration of volatile or semi-volatile compounds and methods thereof. The system includes a fluid path having a first end configured to be operably coupled to a fluid source and a second end configured to be operably coupled to the analytical instrument. A solid sorbent is disposed along the fluid path and is configured to absorb an analyte. The flow of fluid along the fluid path from the first end to the second end causes absorbed analyte to be desorbed from the solid sorbent at a desired concentration to the instrument.
Claims17
A method for solventless calibration, the method comprising:
- positioning a microcalibrator in fluid communication with an analytical instrument, the microcalibrator comprising:
- a first solid sorbent along a fluid path and configured to absorb an analyte at a first concentration;
- and
- a second solid sorbent along the fluid path and configured to absorb the analyte at a second concentration;
- said first solid sorbent and second solid sorbent being positioned parallel to each other;
- initiating a fluid flow through the microcalibrator such that the analyte desorbs from the first solid sorbent, the second solid sorbent, or both to the analytical instrument;
- and
- generating a calibration curve from the measured responses of the analytical instrument relative to the analyte desorbed at the first and second concentrations.
A method for solventless calibration, the method comprising:
- positioning a microcalibrator in fluid communication with an analytical instrument, the microcalibrator comprising:
- a first solid sorbent along a fluid path and configured to absorb an analyte at a first concentration;
- and
- a second solid sorbent along the fluid path and configured to absorb the analyte at a second concentration;
- said first solid sorbent and second solid sorbent being positioned parallel to each other;
- initiating a first fluid flow through the microcalibrator such that the analyte desorbs from the first solid sorbent, the second solid sorbent, or both to the analytical instrument at the first and second concentrations, respectively;
- and
- initiating a second fluid flow through the microcalibrator such that the analyte desorbs from the first solid sorbent, the second solid sorbent, or both to the analytical instrument at a third concentration and a fourth concentration, respectively.
Dependencies are inferred from the claim text.