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US 12,233,137 B1Granted
PSMA targeted radiohalogenated urea-polyaminocarboxylates for cancer radiotherapy
AssigneesThe Johns Hopkins University, Duke University
InventorsMartin G. Pomper, Ronnie C. Mease, Vivek Kumar, Sangeeta Ray, Michael Zalutsky, Ganesan Vaidyanathan
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Abstract
Small molecule radiohalogenated PSMA inhibitors and metal complexes thereof and their use in radioimaging and radiotherapy for treating PSMA-related diseases, including prostate cancer, are disclosed. The combination of small molecule radiohalogenated PSMA inhibitors with a competitive PSMA ligand for reducing off-target accumulation of the radiohalogenated PSMA inhibitor also is disclosed.
Claims20
A compound of the following formula:
- wherein:
- p is an integer selected from the group consisting of 1, 2, 3, 4, 5, and 6;
- and
- X is halogen;
- X1 is —CR3 or N, wherein R3 is H or C1-C4 alkyl;
- and
- X2 is selected from the group consisting of a radioisotope of iodine, a radioisotope of bromine, and a radioisotope of astatine;
- and
- wherein M+ is a metal, which can be present or absent.
6 more elements
Dependencies are inferred from the claim text.