Covalently-modified steroid acid-peptides having enhanced stability and/or biological activity
AssigneeDefence Therapeutics Inc.
InventorSimon Beaudoin
Life of this patent
Estimating the term…
Abstract
Steroid acid-peptide conjugates covalently modified for improved stability and/or biological activity are described herein. Covalent modifications include the formation of multimeric compounds comprising at least two steroid acid-peptide monomers covalently bound to one another that behave as new chemical entities, as well as protecting one or more free thiol groups present in the steroid acid-peptide conjugates to improve their stability and/or biological activity.
Claims19
A multimeric compound comprising two monomers covalently bound to one another via an intermolecular disulfide bond, each monomer comprising a bile acid-peptide conjugate, wherein the peptide comprised in the monomers comprises a nuclear localization signal (NLS), wherein the bile acid comprised in the monomers mediates endosomal escape of the multimeric compound.
Dependencies are inferred from the claim text.