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US 12,233,120 B2Granted
Proteins and immunizing compositions containing Pasteurella proteins and methods of use
AssigneeVaxxinova US, Inc.
InventorsCharles Nelson Carver, III, Daryll Emery
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Abstract
The present invention provides isolated proteins isolatable from a Pasteurella spp. such as P. multocida. Also provided by the present invention are compositions that include one or more of the proteins, and methods for making and methods for using the proteins.
Claims15
A composition comprising a bacterium, the bacterium comprising:
- (i) a protein having at least 90% similarity to amino acids 25-968 of SEQ ID NO:
- 2, a protein having at least 90% similarity to amino acids 27-780 of SEQ ID NO:4, and a protein having at least 90% similarity to amino acids 23-727 of SEQ ID NO:6;
- or
- (ii) a protein having at least 90% similarity to amino acids 25-964 of SEQ ID NO:
- 8, a protein having at least 90% similarity to amino acids 26-848 of SEQ ID NO:10, a protein having at least 90% similarity to amino acids 27-784 of SEQ ID NO:12, and a protein having at least 90% similarity to amino acids 25-742 of SEQ ID NO:14;
- and
- an adjuvant.
4 more elements
A composition comprising two or more bacteria, wherein each bacterium expresses a subset of proteins selected from
- a protein having at least 90% similarity to amino acids 25-968 of SEQ ID NO:2,
- a protein having at least 90% similarity to amino acids 27-780 of SEQ ID NO:4,
- a protein having at least 90% similarity to amino acids 23-727 of SEQ ID NO:6,
- a protein having at least 90% similarity to amino acids 25-964 of SEQ ID NO:8,
- a protein having at least 90% similarity to amino acids 26-848 of SEQ ID NO:10,
- a protein having at least 90% similarity to amino acids 27-784 of SEQ ID NO:12, and
- a protein having at least 90% similarity to amino acids 25-742 of SEQ ID NO:14;
- and
- an adjuvant, wherein the two or more bacteria when considered as a whole express all of proteins, and wherein each bacterium of the two or more bacteria express at least two of the proteins.
6 more elements
Dependencies are inferred from the claim text.