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US 12,233,091 B2Granted
Vaccine compositions and methods
AssigneeMirror Biologics, Inc.
InventorMichael Har-Noy
Life of this patent
Estimating the term…
Abstract
The present invention relates to pharmaceutical vaccine compositions comprising at least one vaccine antigen together with living immune cells. These immune cells include at least a portion of activated T-cells and act as an adjuvant. Methods for using these pharmaceutical compositions to prevent or treat diseases, such as cancer, infectious diseases and autoimmune disease are also included.
Claims14
A method of reducing antigens from a tumor in a host comprising:
- administering a pharmaceutical composition comprising an adjuvant and one or more antigens,
- wherein the source of one or more antigens is chaperone rich cell lysates (CRCL), wherein the source of the CRCL is the tumor and the CRCL comprises multiple chaperone complexes enriched by free solution-isoelectric focusing, the multiple chaperone complexes comprising GRP94/gp96, HSP90, HOSP70 and calreticulin,
- wherein the adjuvant comprises living immune cells, wherein the immune cells comprise activated T-cells that are allogeneic to the host, the T-cells comprising memory Th1 cells activated by cross-linking CD3 and CD28 surface molecules, and
- wherein the pharmaceutical composition, upon administration to the host, stimulates a Th1 immune response in the host to the one or more antigens in the composition, thereby stimulating a Th1 immune response in the host against the antigens from the tumor.
1 more element
Dependencies are inferred from the claim text.